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Prof. George Birkmayer

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Questions and answers

The discovery of NADH can be traced back to the biochemist Sir Arthur Harden in
1906. Harden and his colleague William Young conducted experiments on yeast
to find out how sugar is converted into alcohol. In the process
they discovered that the enzyme zymase produces NADH when it breaks down sugar.

The discovery of NADH helped to deepen the understanding of
how energy is generated in cells. The coenzyme is necessary to maintain
electron transport in the respiratory chain, activate ATP synthesis to
produce energy. NADH acts as a kind of
"energy store" by accepting electrons during energy production
and then releasing them to other molecules to boost metabolism.

In summary, the discovery of NADH is an important milestone in
biochemistry and has helped to deepen our understanding of how
energy is produced in cells.

Yes, NADH is vegan. It is a pure substance that does not contain animal and animal derived products.

NADH is obtained from yeast, which contains very high amounts of the oxidized form of NADH, NAD+. This NAD+ is then enzymatically converted into NADH. NADH is 99.9% pure substance and also contains no more traces of yeast. 

Yes, as a rule, more NADH also means more ATP, because NADH (nicotinamide adenine dinucleotide hydride) is an important molecule in cellular respiration, which plays a
central role in the electron transport chain process of the mitochondria. NADH serves as an electron and proton donor and starts the process of oxidative phosphorylation, which leads to the production of ATP (adenosine triphosphate), the cell's primary energy source.

During glycolysis and the citrate cycle (also known as the Krebs cycle), NADH is produced from NAD+ by transferring electrons and protons from the breakdown products of glucose and other nutrients to NAD+. The NADH formed in this way then transports the electrons to the electron transport chain in the inner mitochondrial membrane.

In the electron transport chain, the NADH molecules release their electrons, which leads to the release of the energy required to pump protons across the membrane and thus create a proton gradient. The return of protons to the mitochondrial matrix by ATP synthase leads to the production of ATP. Each NADH molecule that enters the electron transport chain can theoretically lead to the production of up to approximately 2.5 to 3 ATP molecules, although this value can vary depending on cell state and conditions.

Consequently, the amount of ATP generated is directly proportional to the amount of NADH available as long as the other components of the system are functional and there is sufficient oxygen to serve as the final electron acceptor. In states where oxygen is limited, such as anaerobic respiration, ATP is generated in a different way that is less efficient and not as dependent on NADH.

The citrate cycle describes a series of chemical reactions that take place in cells to produce energy. This cycle occurs in the mitochondria and is one of the main ways cells produce energy from food. The cycle begins with a molecule of acetyl-coenzyme-A, which is formed from the breakdown of carbohydrates, fats and proteins. This molecule then enters the citrate cycle, where it undergoes a series of reactions that include the formation of NADH.

NAD, NADH and NAD+ are all molecules found in our cells, where they are cellular components involved in our body's natural energy production through the breakdown of food.

NAD stands for nicotinamide adenine dinucleotide, and NAD+ and NADH are only slightly different forms of this molecule.

Put simply, NAD+ is the "active" form of the molecule and, as a cellular component, is involved in processes in which the cell consumes energy. NADH, on the other hand, is the "reduced" form and, as an endogenous substance, is involved in the processes in which energy is produced. So when you supplement NADH, you are getting the more efficient form of NAD. For this reason, we focus exclusively on NADH in our supplements.

NMN is a precursor of NAD, which eventually gives rise to NAD+ or NADH again.

The effect of our Prof. George Birkmayer NADH RAPID can be proven after only 15 minutes with several medical-technical devices (such as heart rate variability=HRV) and also on the ergometer (in fitness centers).

Both products contain about 55 sprays. If you use 3 sprays per day, the 10 ml bottle will last for 18 days.

NADH RAPID is a lozenge that is best placed under the tongue, where it dissolves within 1-2 minutes. The energy-increasing effect of NADH RAPID can be proven after only 15 minutes with several medical-technical devices. NADH CONSTANT is a "swallow tablet" that should be taken with a glass of water on an empty stomach. The NADH in this tablet is then absorbed in the intestine. Therefore, the onset of action can only be observed after 1-1½ hours. Both products contain 20 mg NADH per tablet.

For reasons of shelf life, most tablets are inserted into plastic films that have wells for the tablets. These are then sealed airtight with an aluminum foil. This container is called a blister.

NADH ARTHROS is intended for the construction and regeneration of joint cartilage. Its regeneration takes several months based on the experience of traditional medicine. NADH VISION is intended for the protection of the eye, especially the macula. In order to see the protective effect of NADH VISION, it is necessary to use it preventively for several months.

Based on our more than 20 years of experience with our NADH products, we know that much better and also faster effects have been observed with higher doses.

In our scientific studies, no drug interactions have been observed so far.